Methyldrostonolone, also known as Methasterone , is a powerful oral anabolic steroid that has never been available as a prescription drug. Structurally, this steroid is a closely related derivative of drostanolone ( Masteron ). The difference between these two compounds is only in the addition of the c-17 alpha- methyl group, which ensures high bioavailability of the steroid when taken orally. These two substances, however, remain very comparable. Both Methyldrostonolone and Drostanolone are non- aromatizing steroids, therefore both steroids provide favorable anabolic and androgenic ratios.

Laboratory analyzes put Superdrol first as it has 4 times the anabolic potential of oral methyltestosterone , displaying only 20% androgenicity (20: 1 ratio, compared to 3: 1). However, the accuracy and actual relevance of these figures still has to be confirmed in the future. Methyldrostonolone is prized by athletes for its mild anabolic properties, usually accompanied by fat loss and minimal androgenic side effects. More details here


Methyldrostonolone was first described in 1959. This steroid was developed by the international pharmaceutical giant Syntex., along with other well-known anabolic drugs such as drostanolone and oxymetholone . Unlike drostanolone and oxymetholone , this steroid, however (at least in its basic form), was never marketed as a drug. It was only marketed for a short period of time as the modified hormone Dimetazine. Dimetazine is composed of two Methyldrostonolone molecules bound together and then metabolically separated to produce free Methyldrostonolone .

Thus, although technically Methyldrostonolone itself was never marketed as a prescription drug, it can be said that it was still used in medical practice. On the other hand, molecularly, Methyldrostonolone remains an understudied substance and has never been approved for human use. Methyldrostonolone was released in early 2005 on the gray market for over-the-counter anabolic steroids in the United States.

The drug was sold as a dietary supplement without restriction, except for some minimum age limit set by the manufacturer. No state or federal law identifies this drug as an anabolic steroid, which removes all of the measures associated with steroids as a class III controlled substance. This is due to the fact that Methyldrostonolone was not present on the market at the time of the signing of these laws, and simply was not known to legislators.

However, it was illegal to sell it as a dietary supplement, and in late 2005, the FDA discovered the sale of Methyldrostonolone in the sports supplement market. In early 2006, the FDA sent letters to the manufacturer and distributor asking them to stop selling the drug. Since then, Superdrol has disappeared from the market forever.

How is it supplied?

Methyldrostonolone has never been marketed as a prescription drug. In the form of a food supplement, the drug was produced in the form of capsules containing 10 mg of steroid each.

Structural characteristics

Methyldrostonolone is a modified form of DHT. It differs: 1) the addition of methyl groups on carbon-17-alpha, which helps to protect the hormone when taken orally, and 2) the introduction of a methyl group on carbon-2 (alpha), which significantly increases the anabolic strength of the steroid by increasing its resistance to enzyme metabolism 3 -hydroxysteroid dehydrogenase in skeletal muscle tissue.

Side Effects (Estrogenic)

Methyldrostonolone is not a fragrance in the human body and does not exhibit noticeable estrogenic effects. The use of anti-estrogens is optional when using this steroid, and gynecomastia should not manifest itself even in sensitive individuals. Estrogen usually affects the retention of water in the body, while Methyldrostonolone produces a physique that looks good without excessive fluid retention. This makes it a favorable steroid to use during drying cycles when fluid and fat retention are major concerns.

Side Effects (Androgenic)

Although the steroid is classified as an anabolic, androgenic side effects are common with this substance and may include oily skin, acne, and body / facial hair growth. Anabolic / androgenic steroids can also worsen male pattern baldness. Women should be warned of the potential virilizing effects of anabolic / androgenic steroids. These can include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and an enlarged clitoris.

Methyldrostonolone is a steroid with a relatively low androgenic relative activity, which makes the threshold for severe androgenic side effects relatively higher than with more androgenic substances such as testosterone, methandrostenolone, or fluoxymesterone . Please note that Methyldrostonolone is not affected by the 5-alpha reductase enzyme, therefore the relative androgenicity of the substance does not depend on the simultaneous use of finasteride. 

Side effects ( hepatotoxicity ) 

Methyldrostonolone is a c17-alpha alkaline compound. This protects the drug from deactivation in the liver, allowing a very high percentage of the drug to enter the bloodstream after ingestion. C17-alpha alkaline anabolic / androgenic steroids can be hepatotoxic . Long-term exposure or high dosages can cause liver damage. In rare cases, life-threatening dysfunction may develop.

It is advisable to visit a doctor periodically during each cycle to monitor liver function and overall health. Use of c17-alpha alkylated steroids is usually limited to 6-8 weeks to avoid escalating liver strains. Note that while there is no data to make such claims, private laboratory test results indicate that doses of 10 mg and 20 mg per day are sufficient to increase liver enzyme levels in consumers. In addition, few serious adverse events associated with liver toxicity have been reported with this substance.

When using any hepatotoxic anabolic / androgenic steroid, liver detoxification supplements are recommended .

Side Effects ( Cardiovascular )

Anabolic / androgenic steroids can adversely affect cholesterol levels. This includes trends towards lower HDL (good cholesterol) levels and higher LDL (bad cholesterol) levels, which may contribute to the risk of atherosclerosis. The degree of effect of anabolic / androgenic steroids on serum lipids depends on the dose, route of administration (oral or injectable), type of steroid (aromatized or not), and the level of metabolic resistance in the liver. Methyldrostonolone has a strong influence on the level of cholesterol in the liver due to the fact that this substance is not aromatized, and due to its structure, it is able to resist breakdown in the liver, the route of administration of the drug is also an important condition.

Anabolic / androgenic steroids can also negatively affect blood pressure and triglyceride levels, decrease endothelial relaxation, and promote left ventricular hypertrophy, all of which can potentially increase the risk of cardiovascular disease and myocardial infarction. To reduce the risk of cardiovascular deformities, it is recommended to do vigorous exercise and minimize the intake of saturated fat, cholesterol and simple carbohydrates during the entire period of active use of AAS (anabolic / androgenic steroids). An additional intake of fish oil (4 g per day), natural cholesterol and antioxidants is also recommended.

Side Effects (Testosterone Suppression)

All anabolic / androgenic steroids, when taken in doses sufficient to increase muscle mass, suppress endogenous testosterone production. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months after taking the drug. Note that long-term hypogonadotropic hypogonadism may develop secondary , requiring medical intervention. 

Use (Men) 

Methyldrostanolone has never been approved for human use. Prescribing guidelines are not available. An effective dosage of Methyldrostanolone for physique or performance purposes starts at 10-20 mg per day and is taken no longer than 6-8 weeks. At this level, it provides measurable muscle gain, usually accompanied by fat loss and improved definition. Don’t expect a 30-pound gain from this agent (its name, which is short for ” Super Anadrol “, is more of a marketing ploy than a reality), but many gain more than 10-pound muscle gain when using this drug alone.

When determining the optimal daily dose, some find the drug noticeably more effective when used in doses up to 30 mg. However, at such a dosage, the potential hepatotoxicity of the drug must be taken into account . To avoid further escalation of liver strains, 20 mg of methyldrostonolone daily is recommended to be mixed with non-toxic injectable steroids such as testosterone during the phases of mass gain , or nandrolone or boldenone for leaner muscle gain . It also works well for drying cycles where its lack of estrogenicity is appreciated . It is often combined with a non- aromatizing injectable steroid such as Primobolan or Parabolan .

Use (Women)

Methyldrostonolone has not been approved for human use. Prescribing guidelines are not available. In sports, the oral effective daily dosage is in the range of about 2.5 mg per day, for cycles no longer than 4-6 weeks, which minimizes the side effects of virilization. The main point of controversy is the use of 10 mg per capsule in women, which is too high a dose. It will be necessary to open each capsule and divide the powdered soda into 4 separate doses.